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Combined targeting of growth-promoting genes with antisense oligonucleotides in human colorectal cancer cells: BoxSafat, State of Kuwait.
Aberrant expression of growth-promoting genes contributes to the growth advantage of tumor cells, targeting such genes with phosphorothioated antisense oligonucleotides, AS[S]ODNs, might therefore be useful in controlling the abnormal proliferation of cancer cells.
To explore the potential of combination antigene therapy in human colorectal cancer cells, we have examined the in vitro effects of AS[S]ODNs targeting c-myb, c-myc and cdc2 in human colorectal cancer cell lines. Our study suggests that combination antigene therapy targeting c-myb, c-myc and cdc2 can inhibit human colorectal cancer cell proliferation more effectively than monogene therapy by blocking the cell cycle and inducing apoptosis.
Combination antigene therapy is thus a promising approach for cancer therapy. Introduction of supercritical fluid extraction as a new sample-preparation procedure for isolation and identification of a pharmaceutical from biological fluids: Since its commercial development in the early s, supercritical fluid extraction SFE has attracted considerable attention as a sample-preparation procedure.
Four parameters, including the temperature and the pressure of supercritical fluid, modifier ratios, and dynamic extraction time, were evaluated and optimized to obtain the best yield of the analyte from the biological fluids.
The method showed good a recovery rate The method was successfully applied to estimate the pharmacokinetic variables of orbifloxacin in lactating does.
To the best of our knowledge, this is the first time that SFE has been applied to isolate an antimicrobial agent from biological fluids.
This method is promising for clinical applications and for pharmacokinetic studies of various pharmaceuticals in biological fluids. Every year more than half a million women lose their lives because of complications of pregnancy and childbirth.
Postpartum hemorrhage is the leading cause of death especially in developing countries. Strategies have been developed to prevent and treat postpartum hemorrhage. One of these is the use of uterotonic drugs to prevent and treat atonic postpartum hemorrhage.
Misoprostol prostaglandin E1 analogue has been emerged as an uterotonic drug with special advantages; being heat stable, can be used orally and rather cheap. So, it can be considered as a potential "Magic Bullet" in the management of postpartum hemorrhage.
Because of this potentiality, World Health Organization has been conducting big multicentre randomized clinical trials to evaluate efficacy and safety of misoprostol in the prevention and treatment of postpartum hemorrhage. The findings and implications of these trials will be presented and discussed.
It has been years since Paul Ehrlich popularized the concept of a "magic bullet" during his Nobel prize lecture. Scientists have since keenly embarked on the search for these magic bullets.
In the UK prostate cancer is the most common cancer diagnosed in men and the second leading cause of cancer death in men 1. Consequently a magic bullet is highly desired by patients and urologists alike.
The first bullet comprises hormonal therapy resulting in androgen ablation, which represent the mainstay of treatment of metastatic prostate cancer. LHRH analogues can be implanted into patients where they cause a negative feedback effect, resulting in a decrease in LHRH production from the anterior pituitary and a subsequent reduction in testicular testosterone production.
Brachytherapy is ultrasound guided implanation of radioactive seeds into the prostate. Its popularity has increased as the use of transrectal ultrasound TRUS makes it easier to accurately direct the magic bullet.
Patient selection is a key." I think it is either 1) pointer at a different place in the DNA, or 2) filling of each half of the growing cell with two different kinds of proteins (really all that is needed is an inhibiter to be made and focused in one half of the cell to stop the cell from growing a flagellum for example).
This page intentionally left blank V i s u a l i z i n g geology THIRD EDITION V i s u a l i z i n g geology THIRD EDITION BARBARA MURCK, PHD UNIVERSITY OF TORONTO BRIAN.
Oct 06, · The case is different in many other states where liquor shops are rationed on the basis of the customer base they serve on a regular basis. The excess liquor then goes to other states, most importantly Gujarat,” said an investigator.
Presence of Legionella spp. in Hot Water Networks of Different Italian Residential Buildings: Polymers & Plastics. Surfaces, Coatings & Films. Other. MATHEMATICS & COMPUTER SCIENCE. Algebra & Number Theory. Essay. Hypothesis. Interesting Images. Review. Short Note.
We focus here on a study involving Amyotrophic lateral sclerosis (ALS), Duchenne Muscular Dystrophy (DMD), Spinal muscular atrophy (SMA) and Familial Amyloid Polyneuropathy (FAP), approaching different treatment methods and the reaction mechanisms of several compounds, trying to elucidate new routes capable of assisting in the treatment profile.
Journal of Polymers and the Environment, 20 (2). pp. ISSN Ataei, S.
and Yahya, R. and Gan, S.N. and Hassan, A. () Study of thermal decomposition kinetics of palm oleic acid-based alkyds and effect of oil length on thermal stability. Journal of Polymers and the .